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KMID : 1003219990050010163
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Journal of Korean Oriental Chronic Disease
1999 Volume.5 No. 1 p.163 ~ p.176
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Effect of the extract of Polygonati sibirici Rhizoma on the Nitrite level and the Nitric oxide synthase activity in Rat´s corpus cavernosum penis
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Abstract
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The purpose of this study was to investigate the effect of Polygonati sibirici Rhizoma (PSR) on the urethral nitrite level and the urethral nitric oxide synthase (NOS) activity in streptozotocin (STZ) induced diabetic rats.
In vitro, the urethral NOS activity was not noted in the level of dose of extract prepared from PSR. In vivo, the urethral NOS activity was increased in normal rats and STZ induced diabetic rats by dose and term of extract prerared from PSR. The NOS activity decreased in STZ induced diabetic rats was increased as highly as normal group by the extract of PSR. The level of urethral nitrite and glutathione was increased too. The level of urethral lipid peroxide increased in STZ induced diabetic rats was decreased as lowly as normal group by the extract of PSR.
In conclusion, the extract of PSR will be able to restore erectile dysfunction of STZ induced diabetic rats.
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